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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Amino acid/spermine conjugates: polyamine amides as potent spermidine uptake inhibitors

M R Burns1, C L Carlson, S M Vanderwerf

  • 1Oridigm Corporation, 4010 Stone Way North, Suite 220, Seattle, WA 98103, USA. markburns@oridigm.com

Journal of Medicinal Chemistry
|October 19, 2001
PubMed

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Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
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