Related Experiment Video
Updated: Aug 1, 2026
11:49
Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue
Published on: August 28, 2021
Proteomics in neuroscience: from protein to network
1Department of Neuroscience, University of Edinburgh, Edinburgh EH8-9JZ, United Kingdom. seth.grant@ed.ac.uk
Summary
Proteomics offers new insights into complex biological functions by studying protein networks. This technology is being applied to understand the nervous system
Area of Science:
- Neuroscience
- Proteomics
- Molecular Biology
Background:
- Intracellular protein networks are crucial for neuronal and glial functions.
- The unicellular eukaryote Saccharomyces cerevisiae serves as a model for proteomic studies.
- The nervous system's complexity presents unique challenges for studying protein networks.
Purpose of the Study:
- To discuss the technology of proteomics.
- To explore the applications of proteomics in neuroscience.
Main Methods:
- Proteomic tools and techniques.
- Integration with genomics, microarrays, genetics, and pharmacology.
Main Results:
- Emerging insights into integrated cellular function.
- Addressing technical and biological issues in nervous system proteomics.
Conclusions:
- Proteomics provides a powerful platform for investigating complex biological systems.
- Applications of proteomics are expanding our understanding of the nervous system.
Related Concept Videos
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
01:33Proteomics
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...