Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A method for distinguishing consanguinity and population substructure using multilocus genotype data.

A D Overall1, R A Nichols

  • 1School of Biological Sciences, Queen Mary, University of London, London, England. andy.overall@ed.ac.uk

Molecular Biology and Evolution
|October 19, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Godfrey M Hewitt (1940-2013): highlights in Heredity from a career in evolutionary genetics.

Heredity·2013
Same author

Deletion of selenoprotein P results in impaired function of parvalbumin interneurons and alterations in fear learning and sensorimotor gating.

Neuroscience·2012
Same author

The role of vicariance vs. dispersal in shaping genetic patterns in ocellated lizard species in the western Mediterranean.

Molecular ecology·2011
Same author

Population diversity in batches of the varicella Oka vaccine.

Vaccine·2011
Same author

Sexual preference and genetic correlations.

Trends in ecology & evolution·2011
Same author

Geographically localised bursts of ribosomal DNA mobility in the grasshopper Podisma pedestris.

Heredity·2009

This study distinguishes consanguinity from population subdivision using homozygosity patterns. The method accurately identifies relatedness and estimates genetic parameters in diverse populations.

Area of Science:

  • Population Genetics
  • Human Genetics
  • Statistical Genetics

Background:

  • Excess homozygosity can arise from consanguineous mating or population subdivision (Wahlund effect).
  • Distinguishing these causes is crucial for understanding recessive genetic disorders and forensic calculations.
  • Existing methods may not adequately differentiate between these sources of homozygosity.

Purpose of the Study:

  • To develop and validate a method for distinguishing homozygosity patterns caused by consanguinity versus population subdivision.
  • To accurately estimate the proportion of consanguineous mating (C) and genetic correlation due to subdivision (theta).
  • To apply the method to real-world population data and assess its accuracy with simulated data.

Main Methods:

  • Utilized multilocus genotypic data to analyze patterns of homozygosity.

Related Experiment Videos

  • Calculated a likelihood surface for parameters C (consanguinity) and theta (subdivision).
  • Applied the method to two U.K. Asian populations with differing mating practices and to simulated datasets.

    • Main Results:

    • Successfully differentiated between homozygosity patterns arising from consanguinity and population subdivision.
    • Obtained accurate estimates for C and theta using both real and simulated data.
    • Demonstrated the method's ability to distinguish between cousin marriage and caste endogamy.

    Conclusions:

    • The developed method effectively distinguishes consanguinity from population subdivision using homozygosity patterns.
    • The approach provides accurate estimates of key genetic parameters.
    • The method is extendable to include closer degrees of inbreeding, such as selfing, and considers deeper ancestral relatedness.