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Updated: Jun 29, 2026
Minimal Erythema Dose (MED) Testing
Published on: May 28, 2013
Medium-dose UVA1 phototherapy in localized scleroderma and its effect in CD34-positive dendritic cells
N R Camacho1, J E Sánchez, R F Martin
1Department of Dermatology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico 00936-5067.
Background:
UVA1 radiation seems to be effective in morphea. CD34+ dendritic cells are significantly decreased in lesional skin of morphea patients.
Objective:
We evaluated the therapeutic effectiveness of medium-dose UVA1 phototherapy in localized scleroderma and its effect in the number of dermal CD34+ dendritic cells in skin biopsy specimens of these patients.
Method:
Patients were irradiated with UVA1 (30 J/cm(2)) 30 times. Dermal CD34+ dendritic cells were counted before and after therapy.
Results:
There was clinical improvement after UVA1 irradiation. Dermal CD34+ dendritic cells significantly increased after UVA1 irradiation.
Conclusion:
Medium-dose UVA1 therapy is effective in the treatment of localized morphea. Effectiveness is associated with an increase in the number of CD34+ dendritic cells in the dermis.
