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Fatal graft-versus-host disease following HLA-mismatched donor lymphocyte infusion
1Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Sick Children, London, UK.
Bone Marrow Transplantation
|October 19, 2001
Abstract:
We report the case of a 10-year-old boy with molecular relapse of CML following unrelated donor BMT who developed fatal grade 4 acute GVHD of the gut and liver following one antigen-mismatched donor lymphocyte infusion. Previous experience of donor lymphocyte infusion in the HLA-mismatched setting is reviewed and the role of adoptive immunotherapy in this situation is discussed.