Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Siebold's mydriatic eyedrops].

M Miyazaki1

  • 1The Japanese Society for History of Pharmacy.

Yakushigaku Zasshi
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Two historical prescriptions attributed to Von Siebold reveal the use of Ex Belladonna and Ex Hyoscyamus eye drops for various ocular conditions, not just mydriasis. These findings shed light on historical ophthalmological practices.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD4 subsets in IgA nephropathy.

The Tokai journal of experimental and clinical medicine·1992
Same author

Magnetic resonance imaging of the brain structures in the posterior fossa in retarded autistic children.

Acta paediatrica (Oslo, Norway : 1992)·1992
Same author

Antiproliferative effects of suramin on human cancer cells in vitro and in vivo.

Acta medica Okayama·1992
Same author

[Polymorphism of immunoglobulin heavy chain switch region in IgA nephropathy].

Nihon rinsho. Japanese journal of clinical medicine·1992
Same author

[Hepatic protein synthesis and cytokines in obstructive jaundice].

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology·1992
Same author

[Vincristine played a pivotal role in hematological remission of thrombotic thrombocytopenic purpura (T.T.P.)].

[Rinsho ketsueki] The Japanese journal of clinical hematology·1992
Same journal

"Terumeru," A Patent Medicine of the Late Edo Era-The Packaging, Efficacy Statement, and Dosage Form.

Yakushigaku zasshi·2018
Same journal

Transition of Psychotropic Drugs in Japanese Pharmacopoeia (JP) (Part 18) The Study for New Knowledge and Decisions regarding Cultivation Method for Japanese Valerian (Kisso).

Yakushigaku zasshi·2018
Same journal

History of French Pharmaceutical Education from 16th Century up to the Present􁴷Study on Japanese Pharmaceutical Education : Comparison between Japan and France - Pharmaceutical Education System.

Yakushigaku zasshi·2018
Same journal

Transition of Psychotropic Drugs in Japanese Pharmacopoeia (JP) (Part 17) Transitions in the Standards and Test Methods of Valproic Acid and Sodium Valproate in Japanese Pharmacopoeia (JP), Pharmacopoeia of the USA (USP), British Pharmacopoeia (BP), and the Knowledge and Judgment about Japanese Valeriana, and Valproic Acid from Valeric Acid

Yakushigaku zasshi·2018
Same journal

The Change of Reference to Post-Marketing Surveillance Based on the Sequence of Revising the Pharmaceutical Affairs Law.

Yakushigaku zasshi·2018
Same journal

Historical and Hygienic Aspects on Roles of Quality Requirements for Antibiotic Products in Japan : Part 3-Introduction of Technology and Knowledge in the Production Process and Quality Control of Penicillin from the United States of America.

Yakushigaku zasshi·2018
See all related articles

Area of Science:

  • Historical Medicine
  • Ophthalmology
  • Pharmacology

Background:

  • Two previously uncatalogued prescriptions, potentially authored by Von Siebold, were identified in Nagasaki City and Ohzu City.
  • Handwriting analysis supports the attribution of the second prescription to Von Siebold, despite the absence of a signature.

Discussion:

  • The prescriptions primarily feature Ex Belladonna and Ex Hyoscyamus, known mydriatics.
  • Evidence suggests these formulations were intended for multiple therapeutic effects, including antiphlogistic, analgesic, and anticonvulsant actions in eye diseases, beyond simple mydriasis.

Key Insights:

  • Historical mydriatics like Ex Belladonna and Ex Hyoscyamus were utilized at approximately 1% concentration for procedures such as cataract surgery, as indicated by historical pharmacopeia records (JP III and JP V).

Related Experiment Videos

  • Prescription 1 details a complex formulation for a male patient, including Laudanum and Barium chloride.
  • Prescription 2, intended for a patient in Narutaki, presents a simpler composition.

    • Outlook:

    • Further investigation into Von Siebold's complete medical records could provide more context on these prescriptions.
    • Comparative analysis with other historical ophthalmological texts may reveal broader trends in the treatment of eye diseases during this period.
    • The dual-purpose application of mydriatic agents highlights the evolving understanding of ocular pharmacology and therapeutics.