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Related Experiment Videos

Screening procedures for neuroblastoma: false-negative results.

R E Johnsonbaugh, R Cahill

    Pediatrics
    |August 1, 1975
    PubMed
    Summary

    Simpler urine tests for 3-methoxy-4-hydroxymandelic acid (VMA) may miss neuroblastoma cases. Test sensitivity depends on VMA concentration, which varies, making these methods unreliable for diagnosis or monitoring.

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    Area of Science:

    • Pediatric Oncology
    • Clinical Chemistry
    • Biochemical Diagnostics

    Background:

    • Elevated 3-methoxy-4-hydroxymandelic acid (VMA) excretion is a common indicator in neuroblastoma patients.
    • Simpler urinary VMA detection methods, such as the LaBrosse spot test and VMA test strips, have been developed.

    Purpose of the Study:

    • To evaluate the sensitivity and reliability of rapid screening methods for urinary VMA in neuroblastoma detection and follow-up.

    Main Methods:

    • Analysis of VMA concentration in 24-hour urine samples from neuroblastoma patients.
    • Comparison of VMA concentration sensitivity versus total VMA excretion.

    Main Results:

    • The sensitivity of rapid VMA tests relies on urine VMA concentration, not total excreted VMA.
    • Urinary VMA concentration can fluctuate significantly between patients and daily, even with elevated total excretion.

    Conclusions:

    • Rapid screening methods for urinary VMA are potentially insensitive for diagnosing or monitoring neuroblastoma.
    • These methods require a high VMA concentration, which is not consistently present, limiting their sole use in clinical practice.

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