Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scopolamine and amphetamine effects on discrimination: interaction with stimulus control.

C Ksir

    Psychopharmacologia
    |July 23, 1975
    PubMed
    Summary

    Drug effects on behavior depend on stimulus control. Scopolamine and d-amphetamine impaired performance more under weak stimulus control, suggesting susceptibility to drug action rather than specific drug interactions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Methodology for coupling local application of dopamine and other chemicals with rapid in vivo electrochemical recordings in freely-moving rats.

    Journal of neuroscience methods·1999
    Same author

    Effects of the calcium channel blocker nimodipine on nicotine-induced locomotion in rats.

    Psychopharmacology·1996
    Same author

    Nicotine effects on dopamine clearance in rat nucleus accumbens.

    Journal of neurochemistry·1996
    Same author

    Nicotine enhances dopamine clearance in rat nucleus accumbens.

    Progress in neuro-psychopharmacology & biological psychiatry·1995
    Same author

    Acute and chronic nicotine effects on measures of activity in rats: a multivariate analysis.

    Psychopharmacology·1994
    Same author

    Acute tolerance to the locomotor stimulant effects of nicotine in the rat.

    Psychopharmacology·1991

    Area of Science:

    • Neuroscience
    • Behavioral Pharmacology
    • Psychopharmacology

    Background:

    • Understanding how drugs affect behavior is crucial in neuroscience.
    • Stimulus control significantly influences behavioral responses.
    • Investigating drug interactions with stimulus control provides insights into neural mechanisms.

    Purpose of the Study:

    • To parametrically examine the interaction between drug-induced behavioral changes and predrug stimulus control.
    • To assess the effects of scopolamine, d-amphetamine, and methylscopolamine on behavior under varying stimulus distinctiveness.
    • To determine if observed drug-behavior interactions are specific or related to general susceptibility.

    Main Methods:

    • Rats were trained on a discrete-trial simultaneous discrimination task.
    • Stimulus distinctiveness was systematically varied across six levels.
    • Graded doses of scopolamine, d-amphetamine, and methylscopolamine were administered.

    Main Results:

    • Scopolamine and d-amphetamine showed no increased error rate under strong stimulus control.
    • Both drugs exhibited dose-related increases in error rate under weak stimulus control.
    • Methylscopolamine had minimal effects on error rate and no significant interaction with stimulus control.
    • Scopolamine and methylscopolamine decreased the number of trials responded to, unlike d-amphetamine.

    Conclusions:

    • The interaction between drug effects and stimulus control reflects behavioral susceptibility to drug action.
    • This finding suggests a common mechanism underlying the observed drug-behavior interactions for scopolamine and d-amphetamine.
    • Behavioral pharmacology research must consider stimulus control when evaluating drug effects.

    Related Experiment Videos