Pharmacological actions of some simple analogues of reserpine. I. Analgesic effects

In view of the fact that reserpine treatment lowers pain threshold, structural analogues of reserpine molecule were tested against thermal and visceral pain. Some compounds belonging to piperidino- and morpholino derivatives of acetanilide showed promising analgesic activity. These compounds in earlier studies had shown tranquillizing effect. Combination studies with meperidene, phenylbutazone, phenazone and meprobamate did not significantly change the analgesic activity in thermal methods but the test-compounds were potentiated by phenylbutazone and phenazone in writhing test.