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Updated: Jul 25, 2026

Assessment of Hippocampal Dendritic Complexity in Aged Mice Using the Golgi-Cox Method
Published on: June 22, 2017
Camillo Golgi on the structure of the hippocampus
1Hedco Neuroscience Building, The University of Southern California, Los Angeles.
Abstract:
Golgi's only paper on the pes Hippocampi major was published in 1883 and then reprinted and translated a number of times. In it he stated that the fascia dentata provided the best information available to date on how nerve fibers and nerve cells are related. Based on the revolutionary silver chromate method he had introduced a decade earlier, Golgi described two sources of axons from the fascia dentata: one consisted of direct axons from the granule cells, and the other coonsisted of indirect axons from a diffuse neural net or reticulum that was generated from collaterals of the direct axons. The same basic arrangement was described for Ammon's horn, but neither was illustrated, and it is important to bear in mind that this work was published before the "neuron doctrine" and "law of functional polarity" were elaborated in the 1890's.
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