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The first record on the hereditary concepts on the nature of heredity and its mechanism, dates back to the 5th, 6th century B.C. The most prominent representatives are philosophers and people of Medicine, their views reflecting the priority philosophical systems in ancient Hellas. During the Middle Ages pre-formation theories have been the predominant ones with representatives of the two major trends: ovalists and antimaculists. The ancient Hypothetical concepts for the hereditary processes which go back to the Bulgarian Middle Ages are associated with the first Bulgarian Encyclopedia "Shestodnev" by Joan Ekzarh. The hypothetical concepts on the heredity reflect the theoretical concepts of their authors and find their indirect reflection in Bulgaria by way of the literature in translation which has been wide spread. During the period of the Revival there has been wide spread. During the period of the Revival there has been a strong influence on the concepts of P. Beron, D. Mutev and V. Beron exerted by the mechanical paradigm of the 18th Century. There have been spread widely also the descriptions of the hereditary phenomena in the Bulgarian literature of the Revival.