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Related Experiment Videos

Vitamin B6 deficiency in uremia.

W J Stone, L G Warnock, C Wagner

    The American Journal of Clinical Nutrition
    |September 1, 1975
    PubMed
    Summary

    Uremic patients show significant vitamin B6 deficiency, with lower levels of pyridoxal-5-phosphate (PLP) and related enzymes. Hemodialysis may further impact the erythrocyte glutamic-oxaloacetic transaminase (EGOT) apoenzyme levels.

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    Area of Science:

    • Biochemistry
    • Clinical Nutrition
    • Nephrology

    Background:

    • Uremia is associated with various metabolic derangements.
    • Vitamin B6 (pyridoxine) is crucial for numerous enzymatic reactions, including amino acid metabolism.

    Purpose of the Study:

    • To investigate vitamin B6 status in uremic patients.
    • To compare vitamin B6 markers between hemodialyzed and undialyzed uremic patients and healthy controls.

    Main Methods:

    • Measurement of plasma pyridoxal-5-phosphate (PLP), plasma glutamic-oxaloacetic transaminase (PGOT), and erythrocyte glutamic-oxaloacetic transaminase (EGOT) in 29 uremic patients and normal subjects.
    • Assessment of EGOT activity stimulation by exogenous PLP (EGOT index).

    Main Results:

    • Uremic patients exhibited significantly lower mean plasma PLP, PGOT, and EGOT levels compared to normal controls.
    • Hemodialyzed patients showed a reduced EGOT index, suggesting potential alterations in the EGOT apoenzyme.
    • Undialyzed uremic subjects displayed a higher than normal EGOT index.

    Conclusions:

    • Uremic patients demonstrate significant vitamin B6 deficiency.
    • Hemodialysis may be associated with decreased amounts of the EGOT apoenzyme in uremic individuals.

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