Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Barbital overdose and abuse.

D N Bailey, P I Jatlow

    American Journal of Clinical Pathology
    |September 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Barbital overdose is a growing concern, with high serum concentrations observed in patients who recovered with conservative care. Urine drug screening detected 16 barbital abusers in 1974.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The ulnar nerve in the cubital tunnel: a foetal study.

    Folia morphologica·2021
    Same author

    COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers.

    The pharmacogenomics journal·2013
    Same author

    Effect of coadministered drugs and ethanol on the binding of therapeutic drugs to human serum in vitro.

    Therapeutic drug monitoring·2001
    Same author

    Cocaine and cocaethylene binding to normal human brain and Alzheimer disease brain.

    Therapeutic drug monitoring·2000
    Same author

    Effects of lamotrigine on behavioral and cardiovascular responses to cocaine in human subjects.

    The American journal of drug and alcohol abuse·2000
    Same author

    Binding of antiarrhythmic drugs to human placenta in vitro.

    Annals of clinical and laboratory science·1999
    Same journal

    Invasive urothelial carcinoma in association with surface low-grade papillary urothelial carcinoma: clinical and pathologic insights from a rare entity.

    American journal of clinical pathology·2026
    Same journal

    CEACAM1 expression by immunohistochemistry in B-cell lymphomas and plasma cell myeloma.

    American journal of clinical pathology·2026
    Same journal

    Comprehensive multicriteria life cycle assessment of biopsy processing in a surgical pathology department.

    American journal of clinical pathology·2026
    Same journal

    Prognostic significance of Myb protein and its downstream target genes in lacrimal gland adenoid cystic carcinoma.

    American journal of clinical pathology·2026
    Same journal

    Mismatch repair protein "nonclassic expression loss" pattern in colorectal cancer: an important staining pattern that is not well understood.

    American journal of clinical pathology·2026
    Same journal

    Musculoskeletal pain in medical laboratory personnel: a cross-sectional study.

    American journal of clinical pathology·2026
    See all related articles

    Area of Science:

    • Toxicology
    • Clinical Pathology
    • Forensic Science

    Background:

    • Barbital, primarily used in laboratory buffers, is not a regulated pharmaceutical in the US.
    • Historically, barbital overdose and abuse were rare due to limited availability.

    Observation:

    • Eight recent cases of barbital overdose and abuse were documented.
    • Barbital was often obtained by theft from clinical or research laboratories.
    • Serum barbital concentrations were exceptionally high, exceeding those of other barbiturates.

    Findings:

    • Patients with serum concentrations up to 120.2 mg/dL survived with conservative therapy, including those with levels considered lethal for other barbiturates.
    • Patients regained consciousness when serum concentrations fell below 16.0 mg/dL.

    Related Experiment Videos

  • Serum concentrations exceeding 20.0 mg/dL strongly suggest barbital ingestion.

    • Implications:

    • Clinicians should consider barbital poisoning in cases of severe barbiturate intoxication, especially with unusually high serum levels.
    • The findings highlight the need for increased vigilance and screening for barbital abuse.
    • This study underscores the potential for misuse of laboratory chemicals and the importance of secure storage.