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Familial pseudomembranous colitis and its relation to lincomycin therapy
The American Journal of Digestive Diseases
|September 1, 1975
Summary
Severe pseudomembranous colitis occurred in a father and his two children. Two family members used lincomycin before symptoms, suggesting a potential pharmacogenetic link to antibiotic-induced colitis.
Area of Science:
- Gastroenterology
- Pharmacology
- Genetics
Background:
- Antibiotic-associated diarrhea is a common clinical issue.
- Pseudomembranous colitis is a severe form of antibiotic-associated colitis.
Observation:
- Three members of a single family presented with severe pseudomembranous colitis.
- Two affected individuals had recently received lincomycin.
Findings:
- The familial occurrence suggests a potential genetic predisposition.
- A possible pharmacogenetic interaction with lincomycin is indicated.
Implications:
- This case highlights the need to consider genetic factors in antibiotic-induced colitis.
- Further research into pharmacogenetics may elucidate mechanisms of severe colitis.