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Familial pseudomembranous colitis and its relation to lincomycin therapy

M J Harrod, M S Brown, A G Weinberg

    The American Journal of Digestive Diseases
    |September 1, 1975
    PubMed

    Insights

    Severe pseudomembranous colitis occurred in a father and his two children. Two family members used lincomycin before symptoms, suggesting a potential pharmacogenetic link to antibiotic-induced colitis.

    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Genetics

    Background:

    • Antibiotic-associated diarrhea is a common clinical issue.
    • Pseudomembranous colitis is a severe form of antibiotic-associated colitis.

    Observation:

    • Three members of a single family presented with severe pseudomembranous colitis.
    • Two affected individuals had recently received lincomycin.

    Findings:

    • The familial occurrence suggests a potential genetic predisposition.
    • A possible pharmacogenetic interaction with lincomycin is indicated.

    Implications:

    • This case highlights the need to consider genetic factors in antibiotic-induced colitis.
    • Further research into pharmacogenetics may elucidate mechanisms of severe colitis.

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