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Related Experiment Videos

Reflex sympathetic changes in aortic diastolic pressure-diameter relationship.

M Pagani, P J Schwartz, V S Bishop

    The American Journal of Physiology
    |August 1, 1975
    PubMed
    Summary
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    Nerve stimulation reflexively reduced thoracic aortic diameter in cats, impacting aortic mechanoreceptor sensitivity. This suggests a role for aortic reflex control in cardioaortic coupling.

    Area of Science:

    • Cardiovascular Physiology
    • Autonomic Nervous System Regulation
    • Aortic Mechanics

    Background:

    • The thoracic aorta's diameter influences cardiovascular function and mechanoreceptor sensitivity.
    • Autonomic nervous system pathways modulate vascular tone and cardiac function.

    Purpose of the Study:

    • To investigate the reflex control of thoracic aortic diameter.
    • To determine the impact of sympathetic nervous system stimulation on aortic pressure-diameter relationships.
    • To explore the role of aortic reflex control in cardioaortic coupling.

    Main Methods:

    • Measurements of aortic blood pressure (AP) and external diameter (AD) in anesthetized, vagotomized cats.
    • Generation of sinusoidal aortic volume oscillations using a piston pump.

    Related Experiment Videos

  • Recording of diastolic pressure-diameter relationship (PDR) curves under control and stimulated conditions.
  • Stimulation of the left inferior cardiac nerve (ICN) and the decentralized thoracic sympathetic chain (SC).

    • Main Results:

    • ICN stimulation reflexively shifted PDR curves to lower aortic diameters, particularly when carotid arteries were occluded (mean deltaAD 3.2%).
    • A smaller response was observed with one patent carotid artery (mean deltaAD 2.3%).
    • Sympathetic chain (SC) stimulation elicited similar reductions in aortic diameter (mean deltaAD 3.4%).

    Conclusions:

    • Reflex sympathetic stimulation effectively reduces thoracic aortic diameter.
    • This aortic reflex control mechanism may be crucial for cardioaortic coupling.
    • The findings suggest an influence on aortic mechanoreceptor sensitivity.