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A Rat Surgical Skin Wound Model: An Approach for Wound Healing Studies and Biomaterial Evaluation
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A historical review of wound treatments in animals

J B Mulder1

  • 1Department of Pharmacology and Toxicology, University of Arizona, Tucson.

Veterinary Heritage : Bulletin of the American Veterinary History Society
|June 1, 1994
PubMed
Abstract

No abstract available in PubMed .

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...