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Related Concept Videos

Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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Related Experiment Video

Updated: Jul 4, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Lymphoid neoplasms.

D G Oscier1, A C Gardiner

  • 1Department of Haematology, Royal Bournemouth Hospital, Castle Lane East, Bournemouth, BH7 7DW, UK.

Best Practice & Research. Clinical Haematology
|October 20, 2001
PubMed
Summary
This summary is machine-generated.

Recurring chromosome translocations are common in B cell lymphomas and can aid in diagnosis and detecting minimal residual disease. Secondary chromosomal events like aneuploidy offer prognostic insights for lymphoma subtypes.

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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

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Last Updated: Jul 4, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

Area of Science:

  • Hematology
  • Oncology
  • Cytogenetics

Background:

  • Recurring chromosome translocations are hallmarks of most B cell lymphomas and some T cell lymphomas.
  • These translocations often involve immunoglobulin or T cell receptor loci, leading to altered proto-oncogene expression or novel fusion proteins.
  • Secondary chromosomal abnormalities, such as aneuploidy and deletions, are frequent and provide prognostic information.

Purpose of the Study:

  • To review the role of chromosomal abnormalities in lymphoma diagnosis and prognosis.
  • To discuss the molecular consequences of these abnormalities.
  • To outline appropriate detection methods for various lymphoma subtypes.

Main Methods:

  • Global genomic analysis using G banding, 24-colour fluorescence in situ hybridization (FISH), and comparative genomic hybridization (CGH).
  • Specific investigations including locus-specific FISH probes, polymerase chain reaction (PCR) techniques, and monoclonal antibody analysis.
  • Review of known molecular consequences and detection strategies for lymphoma subtypes.

Main Results:

  • Chromosome translocations are key diagnostic markers and useful for minimal residual disease detection in lymphomas.
  • Aneuploidy and regional deletions, while less specific, are important for prognostic assessment.
  • Different detection methods offer varying levels of specificity and utility depending on the clinical question.

Conclusions:

  • Understanding chromosomal abnormalities and their detection is crucial for accurate lymphoma diagnosis and prognosis.
  • A combination of global and targeted molecular techniques is often necessary for comprehensive lymphoma characterization.
  • The molecular basis of lymphoma pathogenesis is closely linked to its cytogenetic profile.