Deterioration of axotomy-induced neurodegeneration by group IIA secretory phospholipase A2
1Discovery Research Laboratories, Shionogi and Co., Ltd., 12-4 Sagisu 5-Chome, Fukushima-ku, 553-0002, Osaka, Japan. tatsurou.yagami@shionogi.co.jp
Abstract:
Phospholipase A2 (PLA2) is proposed to play a role in the repair of the ruptured membrane after axotomy. In neonatal rats, we examined the effect of Group IIA secretory PLA2 (sPLA2-IIA) on axotomy-induced cell death of motoneurons. sPLA2-IIA significantly induced death of axotomized motoneurons. Indoxam, a specific inhibitor for sPLA2-IIA, protected motoneurons from the sPLA2-IIA-induced deterioration. The present study indicated that sPLA2-IIA possessed neurotoxic effect rather than neuroprotective effect against facial nerve.
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