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Brain histamine and feeding behavior.
T Morimoto1, Y Yamamoto, A Yamatodani
1Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan.
Behavioural Brain Research
|October 20, 2001
Summary
Histamine, a brain chemical, acts as an appetite suppressant. Research using histamine H1-receptor knockout mice reveals its role in regulating food intake and body weight, interacting with leptin signaling.
Area of Science:
- Neuroscience
- Endocrinology
- Physiology
Background:
- Food intake is regulated by central nervous system neurotransmitters and peptides.
- Antihistaminic antidepressants and antipsychotics increase appetite, suggesting histamine's anorectic role.
- Histamine likely decreases food intake via histamine H1-receptors (H1R) in key hypothalamic nuclei.
Purpose of the Study:
- To investigate the role of histamine in regulating food intake.
- To explore the interaction between the histaminergic system and leptin signaling in appetite control.
- To understand the functional associations of histamine with other feeding regulatory neuropeptides.
Main Methods:
- Utilized mutant mice lacking histamine H1-receptors (H1R).
- Examined the interplay between histamine signaling and leptin-induced food intake suppression.
- Investigated functional associations between histamine and neuropeptide Y, peptide YY, and bombesin.
Main Results:
- Demonstrated the involvement of H1R in suppressing food intake.
- Provided evidence for the interaction between the histaminergic system and leptin signaling.
- Identified functional associations of histamine with neuropeptide Y, peptide YY, and bombesin in food intake regulation.
Conclusions:
- Histamine acts as an anorectic agent, primarily through H1R.
- The histaminergic system modulates leptin's effect on food intake.
- Further research is needed to explain the inverse correlation between histamine levels and feeding patterns.