Intraperitoneal chemohyperthermia: rationale, technique, indications, and results

Intraperitoneal chemohyperthermia (IPCH) is a loco-regional treatment for intraperitoneal malignancies. This ultra-radical treatment combines complete cytoreduction of macroscopic peritoneal disease preceding perioperative intraperitoneal perfusion of a chemotherapeutic drug heated to 42 degrees to 44 degrees to treat microscopic residual disease. At present time, this approach is mainly indicated for isolated limited peritoneal carcinomatosis (PC) of colorectal origin and for treatment of low-grade pseudomyxoma peritonei. In selected patients, IPCH may lead to 27% five-year overall survival in cases of PC, and as high as 86% five-year survival in cases of pseudomyxoma peritonei. In the near future, this approach will become the standard treatment for selected cases of PC.