Influence of NBTI on metabolism of brain-HT

The influence of NBTI, an agent which stimulated dopamine receptor in the central nervous system, on concentrations of serotonin and its metabolic, 5-hydroxyindoleacetic acid in the brain of rats was studied. Turnover rate of serotonin in the brain after administration of NBTI to normal rats and those pretreated with spiroperidol, a factor which blocks central dopamine receptors, was evaluated. The changes in metabolism of brain serotonin under the influence of NBTI are similar to those produced by another factor which stimulates central dopamine receptors, namely apomorphine. NBTI causes transient increase in exploratory activity of rats and lowers body temperature.