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Focal organizing pneumonia: CT and pathologic findings
1Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Journal of Korean Medical Science
|October 20, 2001
Summary
Focal organizing pneumonia presents as nodules or masses on CT scans, mimicking lung cancer. CT findings correlate with underlying histopathology, aiding diagnosis.
Area of Science:
- Radiology
- Pathology
- Pulmonology
Background:
- Focal organizing pneumonia (FOP) is a clinicopathologic entity that can mimic lung malignancy on imaging.
- Accurate CT characterization is crucial for differentiating FOP from other lung pathologies.
Purpose of the Study:
- To describe computed tomography (CT) findings of focal organizing pneumonia.
- To correlate CT findings with histopathological results.
Main Methods:
- Retrospective analysis of CT findings in 26 patients with histologically proven FOP.
- Correlation of CT findings with pathological data in 17 surgically resected cases.
Main Results:
- FOP appeared as nodules or masses (9-66 mm) on CT in all patients.
- Ground-glass opacity was present in 46-50% of lesions.
- Lesion margins were smooth, lobulated, or spiculated.
- CT findings correlated with intraalveolar exudate, inflammation, fibrosis, and granulation tissue.
Conclusions:
- CT findings of FOP are variable and can simulate lung cancer.
- Understanding the histopathological basis of CT findings aids in diagnosing FOP.