Related Experiment Video
Updated: Aug 4, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Cervical tuberculous spondylitis associated with systemic lupus erythematosus
M Berker1, B Atalay, F Söylemezoğlu
1Department of Neurosurgery, Hacettepe University School of Medicine, Sihhiye, Ankara, 06100, Turkey.
Spinal Cord
|October 20, 2001
Summary
This case report details a rare instance of cervical tuberculous spondylitis in a patient with systemic lupus erythematosus (SLE). Early diagnosis and treatment are crucial for managing this opportunistic infection in SLE patients.
Area of Science:
- Rheumatology
- Infectious Diseases
- Spinal Surgery
Background:
- Systemic lupus erythematosus (SLE) patients face increased infection risk, particularly those with disease complications.
- Tuberculous spondylitis is an uncommon complication in SLE, with cervical involvement being exceptionally rare.
Observation:
- A 54-year-old female with a 10-year history of SLE, treated with corticosteroids and colchicine, presented with persistent neck pain.
- Radiological findings indicated severe destruction of the C5-C6 cervical vertebrae.
- Surgical intervention involved debridement and anterior cervical fusion with an autogenous bone graft.
Findings:
- The patient was diagnosed with cervical tuberculous spondylitis, a previously unreported manifestation in SLE.
- High-dose corticosteroid therapy for SLE was identified as a significant risk factor for this opportunistic infection.
Implications:
- Highlights the importance of considering opportunistic infections like tuberculosis in SLE patients, especially those on immunosuppressive therapy.
- Emphasizes the need for early diagnosis, prompt medical and surgical management, and heightened clinical awareness to improve outcomes in SLE patients susceptible to infections.
More Related Videos
Related Concept Videos
01:29Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:28Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:26Pulmonary Tuberculosis IV
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
01:28Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...