[Specific interaction of biological molecules. A new method of registration]

The experimental results on influence of some biological molecules and their specific immune complexes on the current-voltage characteristic of surface-barrier contact structures (Ni-Si or PorSiSi) are presented. It was shown that the deposition of the myoglobin and specific to its monoclonal antibodies or its specific immune complex caused the modification of the current-voltage characteristic. Moreover, the structures more essentially react to the formed specific immune complex deposition. The optimum thickness of the metal film or porous silicon layer necessary to the development of maximum response have been obtained. It was concluded that this electrometrical method was suitable for express determination of the formed specific immune complex without separation of it from the initial components of reaction.