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[High density lipoprotein composition in moscovites with low and high HDL cholesterol level]
Insights
High HDL cholesterol in Muscovites doesn't always mean better heart protection. Specific HDL components, like phospholipids, may be altered, reducing its antiatherogenic properties.
Area of Science:
- Lipid metabolism and cardiovascular health.
- Atherosclerosis research.
- Biochemistry of high-density lipoprotein (HDL) particles.
Context:
- Elevated high-density lipoprotein cholesterol (HDL C) is generally considered cardioprotective.
- However, the functional capacity of HDL may vary despite high cholesterol levels.
- Understanding HDL composition is crucial for assessing its true atheroprotective potential.
Purpose:
- To investigate differences in HDL composition between individuals with low and high HDL C levels in a Muscovite male population.
- To identify specific HDL components that might explain reduced antiatherogenic properties in those with elevated HDL C.
Summary:
- Sixty men (40-59 years) were grouped by HDL C levels (low < 40 mg/dl, high > 50 mg/dl).
- Analysis revealed higher apo AI, HDL phospholipids (PL), and altered HDL C/apo AI and HDL C/HDL PL ratios in the high HDL C group.
- The high HDL C group showed a greater proportion of phosphatidylcholine (PC) and less lysoPC within HDL PL.
Impact:
- Findings suggest that elevated HDL C levels in Muscovites may be associated with altered HDL composition.
- These compositional changes, particularly in HDL phospholipids, could underlie diminished HDL antiatherogenic efficacy.
- This highlights the importance of HDL quality over quantity in assessing cardiovascular risk.
Aim:
To elucidate if there are any peculiarities in HDL composition in Muscovites with different HDL C levels, and to reveal which HDL components could determine the disturbances in their antiatherogenic properties at higher HDL C level.
Material And Methods:
Sixty men aged 40-59 years with low HDL C level < 40 mg/dl (36 +/- 0.8 mg/dl; n = 30) and high HDL C level > 50 mg/dl(58 +/- 1.6 mg/dl; n = 30) were compared. Enzymatic, immunonephelometric methods and thin-layer chromatography were used.
Results:
Men with high HDL C level had higher concentration of apo AI, HDL phospholipids (PL), ratios of HDL C/apo AI and HDL C/HDL PL but lower ratio of HDL C free/HDL PL. The analysis of HDL PL composition revealed in subjects with high HDL C higher proportion of phosphatidylcholine (PC) and lower lysoPC, whereas the relative content of sphingomyelin and phosphatidylethanolamine did not differ between the groups.
Conclusion:
The peculiarities in components of HDL found among men with different HDL C levels could explain less effective HDL atheroprotective properties in Muscovites with elevated HDL C.