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Updated: Oct 4, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

[Correlation between severity of angina, its stability, and oxidative modification of lipids in patients with

A L Syrkin, O A Azizov, S V Drinitsina

    Terapevticheskii Arkhiv
    |October 20, 2001
    PubMed

    Insights

    Plasma oxidation resistance increases with angina severity in patients with ischemic heart disease (IHD). This finding offers a new method for assessing IHD severity and stability.

    Area of Science:

    • Biochemistry
    • Cardiovascular Medicine
    • Oxidative Stress Research

    Context:

    • Investigating the relationship between angina pectoris, a symptom of ischemic heart disease (IHD), and plasma oxidation levels.
    • Examining the influence of cardiovascular risk factors such as arterial hypertension (AH) and diabetes mellitus (DM) on lipid oxidation in patients with stable angina.
    • Utilizing copper-induced plasma oxidation assays to dynamically assess lipid oxidation features.

    Purpose:

    • To determine the correlation between the severity and stability of angina and plasma oxidation parameters.
    • To investigate how arterial hypertension and diabetes mellitus impact lipid oxidation in patients with stable angina.
    • To explore the potential of plasma oxidation resistance as a biomarker for assessing IHD severity and stability.

    Summary:

    • The study analyzed 152 patients with stable angina (functional class II-III), including those with concomitant arterial hypertension and diabetes mellitus, alongside patients with unstable angina and healthy donors.
    • Results indicated that the degree of lipid peroxidation increases with the aggravation of angina, suggesting that IHD risk factors promote atherogenic lipid modification.
    • No significant differences in low-density lipoprotein cholesterol content were observed between the patient groups.

    Impact:

    • Plasma oxidation resistance emerges as a potential additional criterion for evaluating the severity and stability of various forms of ischemic heart disease.
    • This research contributes to a deeper understanding of the biochemical processes underlying IHD progression.
    • Findings may lead to improved diagnostic or prognostic tools for cardiovascular disease management.
    Abstract

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