Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Tobramycin ototoxicity: a second look.

R E Brummett, R T Brown

Archives of Otolaryngology (Chicago, Ill. : 1960)

|September 1, 1975

Summary

This summary is machine-generated.

Tobramycin temporarily impairs cochlear potential in guinea pigs, but only when blood pressure drops significantly. This effect is linked to hypotension, not direct tobramycin ototoxicity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Methylphenidate and hospitalized adolescents with conduct disorder: Dose effects on classroom behavior, academic performance, and impulsivity.

Journal of youth and adolescence·2013

Same author

Implication of tyramine in the biosynthesis of morphinan alkaloids in Papaver.

Planta·2013

Same author

TiO2 Photocatalysis for Indoor Air Applications: Effects of Humidity and Trace Contaminant Levels on the Oxidation Rates of Formaldehyde, Toluene, and 1,3-Butadiene.

Environmental science & technology·2011

Same author

Perspective drawing by computer.

Applied optics·2010

Same author

The unexpected preference for the fac-isomer with the tris(5-ester-substituted-2,2'-bipyridine) complexes of ruthenium(II).

Inorganic chemistry·2004

Same author

Behavioral teratology/toxicology: how do we know what we know?

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists·2003

Same journal

Lidocaine in the treatment of Meniere's disease.

Archives of otolaryngology (Chicago, Ill. : 1960)·1985

Same journal

Irradiation after neck dissection.

Archives of otolaryngology (Chicago, Ill. : 1960)·1985

Same journal

Forehead lift.

Archives of otolaryngology (Chicago, Ill. : 1960)·1985

Same journal

Laryngeal cyst of the thyroid cartilage.

Archives of otolaryngology (Chicago, Ill. : 1960)·1985

Same journal

Metabolic facial paralysis in an infant.

Archives of otolaryngology (Chicago, Ill. : 1960)·1985

Same journal

Effects of magnetic resonance imaging fields on stapedectomy prostheses.

Archives of otolaryngology (Chicago, Ill. : 1960)·1985

See all related articles

Area of Science:

Ototoxicology
Pharmacology
Neuroscience

Background:

Tobramycin is an aminoglycoside antibiotic with known nephrotoxic and ototoxic potential.
Previous studies suggest a link between aminoglycoside administration and auditory system dysfunction.

Purpose of the Study:

To investigate the direct ototoxic effects of tobramycin on the cochlear potential in vivo.
To differentiate between direct tobramycin-induced ototoxicity and secondary effects related to hemodynamic changes.

Main Methods:

Intravenous administration of tobramycin to guinea pigs.
Monitoring of alternating current cochlear potential.
Simultaneous measurement of systemic blood pressure.

Main Results:

Related Experiment Videos

Tobramycin administration resulted in temporary impairment of the alternating current cochlear potential.
This impairment was observed exclusively during periods of severe hypotension.
No evidence of permanent cochlear damage or ototoxicity was detected.

Conclusions:

The observed cochlear effects are secondary to tobramycin-induced hypotension.
The data do not support direct ototoxicity of tobramycin at the tested dosage and conditions.
Hypotension is a critical factor to consider when evaluating tobramycin's effects on the auditory system.