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Cocaine-Induced raynaud's phenomenon and ischaemic finger necrosis
A Balbir-Gurman1, Y Braun-Moscovici, A M Nahir
1B. Shine Department of Rheumatology, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa. nahir@rambam.health.gov.il
Clinical Rheumatology
|October 20, 2001
Abstract:
A 37-year-old man with ischaemic finger necrosis and recent-onset Raynaud's phenomenon associated with cocaine abuse is reported. Initial therapy with systemic vasodilators, low-molecular-weight heparin and aspirin failed. Resolution of the ischaemia and ulcer healing was rapidly achieved with intravenous infusions of the prostacyclin analogue iloprost. The mechanism of vascular ischaemic injury and the development of secondary Raynaud's phenomenon due to cocaine use is discussed.