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A unique folate hydrolase, prostate-specific membrane antigen (PSMA): a target for immunotherapy?
1Department of Urology, Memorial Hospital, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Critical Reviews in Immunology
|October 20, 2001
Abstract:
Prostate-specific membrane antigen (PSMA) is a potential target in prostate cancer patients because it is very highly expressed and because it has been reported to be upregulated by androgen deprivation. This review discusses the historical background, biochemical characteristics, gene regulation, potential for targeting, tissue localization, and a novel T-body strategy.