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Mouse fetal antigens in Rauscher leukemia
Bibliotheca Haematologica
|January 1, 1975
Summary
Researchers identified a fetal antigen on virus-induced tumor cells that cross-reacts with embryonic cells. This antigen, distinct from known viral antigens, appears early in embryonic development and is found in specific fetal tissues.
Area of Science:
- Immunology
- Oncology
- Developmental Biology
Background:
- Reports suggest fetal antigens on virus-induced tumor cells.
- Hanna et al. indicated a fetal antigen on Rauscher virus-induced leukemia cells.
Purpose of the Study:
- To investigate cross-reacting antibodies between embryonic cells and Rauscher leukemia cells.
- To characterize a potential fetal antigen on tumor cells.
Main Methods:
- Indirect immunofluorescence test using sera from immunized mice.
- Absorption tests with embryonic cells, adult spleen cells, and thymocytes.
- Analysis of antigen presence during embryonic development and in adult tissues.
Main Results:
- Demonstrated cross-reacting antibodies against embryonic and Rauscher leukemia cells.
- Identified an antigen absorbed by embryonic cells but not adult cells.
- Distinguished this antigen from Gross and Friend-Moloney-Rauscher antigens.
- Antigen detected from 12-day-old embryos, abundant in digestive tract and lung cells.
- Found natural antibodies against this fetal antigen in aged mice.
Conclusions:
- A novel fetal antigen is present on Rauscher leukemia cells and cross-reacts with embryonic cells.
- This antigen is distinct from known viral tumor antigens.
- The antigen's expression pattern suggests a role in early development and potential oncogenesis.