Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell-mediated immunity in human acute leukemia.

R B Herberman, D Char, R Oldham

    Bibliotheca Haematologica
    |January 1, 1975
    PubMed
    Summary

    Patients with acute leukemia show intact cell-mediated immunity against tumor antigens. Skin tests revealed distinct antigens, potentially useful for monitoring leukemia treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    How do forms and characteristics of Asian public housing neighbourhoods affect dementia risk among senior population? A cross-sectional study in Hong Kong.

    Public health·2023
    Same author

    Association between awareness of vulnerability and disaster preparedness in an infrastructure-resilient city: a population-based study.

    Public health·2022
    Same author

    Influence of Urban Green Space and Facility Accessibility on Exercise and Healthy Diet in Hong Kong.

    International journal of environmental research and public health·2019
    Same author

    Periorbital erythema and swelling as a presenting sign of lupus erythematosus in tertiary referral centers and literature review.

    Lupus·2018
    Same author

    Kidneys from standard-criteria donors with different severities of terminal acute kidney injury.

    Transplantation proceedings·2014
    Same author

    Brucellosis in a renal transplant recipient.

    Transplant infectious disease : an official journal of the Transplantation Society·2013

    Area of Science:

    • Immunology
    • Oncology
    • Cell Biology

    Background:

    • Cell-mediated immunity in acute leukemia patients is generally intact but can be affected by disease progression or treatment.
    • Patients with acute leukemia exhibit cellular immune responses against tumor-associated antigens.

    Purpose of the Study:

    • To investigate cellular immune reactivity against tumor-associated antigens in acute leukemia patients.
    • To explore the potential of various immunological assays for monitoring leukemia chemotherapy and immunotherapy.

    Main Methods:

    • Skin tests for delayed hypersensitivity using autologous/allogeneic blast cell membrane extracts and lymphoid cell line extracts.
    • In vitro assays including lymphocyte stimulation and 51Cr release cytotoxicity.
    • Correlation of assay results with disease state (remission vs. relapse).

    Main Results:

    • Skin test reactivity correlated with disease state, being positive in remission and negative in relapse.
    • Lymphoid cell line extracts detected antigens distinct from Epstein-Barr virus (EBV) and those in cytotoxicity assays.
    • Leukemia-associated antigens were identified by lymphocyte stimulation and cytotoxicity, but results did not correlate with skin tests or each other.

    Conclusions:

    • A complex array of antigens exists on leukemia blast cells and lymphoid cell lines.
    • Immunological assays, particularly skin tests, show promise for monitoring acute leukemia treatment.
    • Further research is needed to understand the distinct antigens and optimize assay utility.

    Related Experiment Videos