[Antibody-dependent cytotoxic activity of peripheral blood lymphocytes in healthy subjects]

A method of determining the cytotoxic activity of peripheral blood lymphocytes against Rh-positive erythrocytes labelled with 51Cr and sensitized with anti-D antibody is described. A measure of this activity was the cytotoxic index reflecting the intensity of erythrocytolysis, and expressed as per cent of released 51Cr. The method was applied in investigations of lymphocytes of 54 blood donors. The values of the cytotoxic index ranged from 60% to 94%, the arithmetical mean was 76 +/- 10%. The obtained results are an introduction to further investigations on changes of lymphocytes K in blood diseases.