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[Lymphoblast transformation test in osteoarticular tuberculosis]
Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
|June 1, 1975
Summary
The lymphocyte transformation test (LTT) shows promise for diagnosing osteoarticular tuberculosis. While a negative LTT suggests the absence of tuberculosis, positive results require careful interpretation due to potential cross-reactivity.
Area of Science:
- Immunology
- Orthopedics
- Infectious Diseases
Background:
- Diagnosing osteoarticular tuberculosis, particularly Pott's disease, is challenging due to difficulties in obtaining bacteriological confirmation.
- Previous research in pulmonary tuberculosis suggested the utility of immunological tests.
Purpose of the Study:
- To evaluate the diagnostic value of the lymphocyte transformation test (LTT) for osteoarticular tuberculosis.
- To differentiate tuberculous osteoarticular lesions from other musculoskeletal conditions.
Main Methods:
- The lymphocyte transformation test (LTT) was performed using old tuberculin and LP48 tuberculin at various concentrations.
- Patient groups included those with confirmed tuberculosis (Pott's disease, white tumors) and controls with other osteoarticular conditions.
Main Results:
- Nine out of ten tuberculous patients showed positive LTT results (7 strongly positive), with an average transformation value of 13%.
- Positive LTT results correlated with patient condition, lesion extent, and treatment status.
- Seventeen out of 25 control patients had negative LTT results; 8 were positive, with 2 showing high values (average transformation value of 4%).
Conclusions:
- A negative LTT result is a strong indicator against osteoarticular tuberculosis.
- Weak positive LTT results suggest tuberculin hypersensitivity but do not definitively confirm active tuberculosis.
- Strongly positive LTT results can occur in hyperergic states associated with chronic bone or joint infections.