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Published on: November 10, 2010
Genetic control of chloroform toxicity in mice
Science (New York, N.Y.)
|October 10, 1975
Abstract:
Mouse strain differences suggest intermediate or multifactorial gentic control of chloroform-induced renal toxicity and death. The chloroform dose lethal to 50 percent of animals was four times higher in C57BL/6J males than in DBA/2J males. Twice as much chloroform accumulated in the kidneys of the sensitive as the resistant strain. First generation offspring were midway between parental strains for both parameters.
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