[Approaches to assessing the alimentary load of foreign substances]

The paper presents approaches to estimating alimentary load with foreign substances. At the same time some substances that are strenuously controlled in environmental objects are essential nutrients, this makes it necessary to evaluate a possible adverse effect not only in terms of their toxic significance, but in terms of their physiological requirements. The study has indicated that truly available deficiencies of nutrients may reasonably substantially modify the toxicity of foreign substances, this, if any data on deficiency of essential dietary substances, makes it necessary to specify the storage coefficient of foreign substances by taking into account a possible modifying action on their toxic effects. These data may be also used as an approach to clarifying physiological requirements for essential nutrients.