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Meshy meningioma: a potential novel variant
H Yamanouchi1, H Yokoo, T Yoshida
1First Department of Pathology, Gunma University School of Medicine, Maebashi, Japan. yhideo@dokkyomed.ac.jp
Summary
A novel meningioma variant, termed "meshy meningioma," is described. This rare tumor exhibits unique microscopic and ultrastructural features, distinguishing it from other meningioma types.
Area of Science:
- Neuropathology
- Oncology
Background:
- Meningiomas are tumors arising from the meninges.
- Understanding meningioma variants is crucial for accurate diagnosis and treatment.
Observation:
- A novel meningioma variant with a solid, hard, white, and encapsulated appearance was observed.
- Histopathological examination revealed sparsely cellular tumors with reticular cytoplasm and oval nuclei.
- Immunohistochemistry showed vimentin and epithelial membrane antigen positivity, with negativity for other markers.
Findings:
- Ultrastructural analysis identified bipolar neoplastic cells with long processes forming a mesh-like configuration via desmosomes.
- The cytoplasm and processes were rich in intermediate filaments and rough endoplasmic reticulum.
- These unique microscopic and ultrastructural characteristics differentiate it from known meningioma variants.
Implications:
- The proposed 'meshy meningioma' designation aids in classifying this distinct tumor type.
- Further research into this variant may reveal specific clinical behaviors or therapeutic targets.
- This finding expands the histopathological spectrum of meningiomas.