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Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Synthesis of Azinylvinylpyridazines: A General Note on the Isomerization of Hetaryldienamines
András Kotschy1, György Hajós, G. Timári
1Central Research Institute for Chemistry, Hungarian Academy of Sciences, P.O. Box 17, H-1525 Budapest, Hungary.
Abstract:
Azinyldienamines underwent Diels Alder reaction of inverse electron demand with 1,2,4,5-tetrazine diester to give azinylvinylpyridazines. Comparison of the products obtained from mono-, di-, and triazinyldienamines revealed that, in some cases, isomerization of the olefinic side chain occurred which can be rationalized by the tautomeric conditions of the intermediates bearing these azine moieties. These experimental findings supported also by semiempirical calculations suggest the importance of the influence of the hetaryl group in such isomerizations.
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