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Superior mesenteric blood flow during experimentally induced dumping in man
Acta Chirurgica Scandinavica
|January 1, 1975
Summary
Ingesting glucose rapidly increases superior mesenteric blood flow and dilates small intestine blood vessels. This study investigated blood flow changes during provoked dumping syndrome.
Area of Science:
- Gastroenterology
- Physiology
- Vascular Biology
Background:
- Dumping syndrome is a common complication after gastric surgery.
- Rapid gastric emptying leads to fluid shifts and hormonal changes affecting gut circulation.
Purpose of the Study:
- To quantify changes in superior mesenteric blood flow and vascular resistance during provoked dumping syndrome.
- To elucidate the hemodynamic alterations in the small intestine following glucose load.
Main Methods:
- Dye-dilution technique in 5 patients with catheterization of the superior mesenteric artery and vein.
- Dumping syndrome was provoked by intrajejunal instillation of 150 ml 50% glucose.
- Superior mesenteric angiography was performed at intervals post-provocation.
Main Results:
- Superior mesenteric blood flow increased by an average of 157% within minutes of glucose instillation, peaking at 223% increase.
- Superior mesenteric vascular resistance decreased by 63%, reaching a maximal reduction of 76%.
- The ratio of superior mesenteric blood flow to cardiac output increased from 12% to 27%, indicating significant vasodilation.
Conclusions:
- Intrajejunal glucose instillation provokes a marked, localized increase in superior mesenteric blood flow.
- Significant vasodilation occurs in the small intestine during dumping syndrome, mediated by reduced vascular resistance.
- These findings highlight the dynamic circulatory response of the gut to nutrient delivery.