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Langerhans' cell histiocytosis: temporal bone involvement
G Marioni1, C De Filippis, R Stramare
1Department of Otolaryngology--Head and Neck Surgery, University of Padua, Padua, Italy. g_maroni@virgilio.it
The Journal of Laryngology and Otology
|October 23, 2001
Summary
Langerhans' cell histiocytosis commonly affects the mastoid in the temporal bone. Computed tomography (CT) is the preferred imaging method for assessing disease extent and treatment response.
Area of Science:
- Radiology
- Oncology
- Histiocytosis
Background:
- Langerhans' cell histiocytosis (LCH) is a rare clonal proliferative disease.
- Temporal bone involvement in LCH presents with characteristic destructive bone lesions.
Purpose of the Study:
- To describe the radiological findings of temporal bone involvement in Langerhans' cell histiocytosis.
- To evaluate the role of computed tomography (CT) in assessing disease extent and treatment response.
- To compare the sensitivity of different imaging modalities.
Main Methods:
- Review of radiological findings in patients with histologically confirmed LCH and temporal bone involvement.
- Analysis of computed tomography (CT) scans to delineate lesion extent.
- Comparison of CT findings with bone scintigraphy and radiography.
Main Results:
- Destructive bone lesions predominantly involve the mastoid.
- Squamous part and middle ear are less frequently affected.
- CT is effective in defining lesion extent and monitoring disease activity.
- Bone scintigraphy appears less sensitive than radiography for lesion detection.
Conclusions:
- CT is the preferred imaging modality for evaluating temporal bone LCH.
- CT plays a crucial role in disease monitoring and treatment assessment.
- Radiography may be more sensitive than bone scintigraphy in detecting these lesions.