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Related Experiment Videos

Mortality in severe meningococcal disease.

K Thorburn1, P Baines, A Thomson

  • 1Paediatric Intensive Care Unit, Royal Liverpool Children's Hospital-Alder Hey, Eaton Road, Liverpool L12 2AP, UK. kent.thorburn@rlch-tr.nwest.nhs.uk

Archives of Disease in Childhood
|October 23, 2001
PubMed
Summary

Critically ill children with meningococcal disease have a lower mortality rate now. This study shows improved outcomes in pediatric intensive care units (PICUs) for this serious infection.

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Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Epidemiology

Background:

  • Meningococcal disease remains a significant cause of critical illness in children.
  • Assessing mortality trends in pediatric intensive care units (PICUs) is crucial for evaluating treatment efficacy.

Purpose of the Study:

  • To evaluate the mortality rate of critically ill children admitted with meningococcal disease.
  • To compare current mortality data with historical studies.

Main Methods:

  • A prospective study was conducted on children admitted to a regional PICU between January 1995 and March 1998 with meningococcal disease.
  • Outcome measures included actual overall mortality, predicted mortality using the Pediatric Risk of Mortality (PRISM) score, and standardized mortality ratio (SMR).

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Main Results:

  • A total of 123 children were admitted; 11 (8.9%) died in the PICU.
  • The predicted mortality by PRISM was 24.9, with an observed SMR of 0.44.
  • Compared to four previous studies, the overall PICU mortality and SMR were lower.

Conclusions:

  • Mortality for critically ill children with meningococcal disease has decreased.
  • This improvement is observed even when accounting for disease severity, suggesting advancements in care.