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Related Experiment Videos

Mesenteric venous thrombosis: a changing clinical entity.

M D Morasch1, J L Ebaugh, A C Chiou

  • 1Division of Vascular Surgery, Department of Surgery, Northwestern University Medical School, Chicago, IL 60611, USA.

Journal of Vascular Surgery
|October 23, 2001
PubMed
Summary
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Mesenteric venous thrombosis (MVT) is increasingly diagnosed with CT scans. Early diagnosis and anticoagulation improve survival rates for MVT patients, challenging its historical perception as a morbid condition.

Area of Science:

  • Vascular Surgery
  • Gastroenterology
  • Radiology

Background:

  • Mesenteric venous thrombosis (MVT) diagnosis has improved with advanced imaging.
  • Historically viewed as a severe condition, MVT's prognosis may be better with early intervention.
  • Identifying and treating underlying hypercoagulable states is crucial for MVT management.

Purpose of the Study:

  • To evaluate the diagnostic methods and management strategies for MVT.
  • To review the long-term treatment outcomes for patients with MVT.
  • To assess the current mortality rates of MVT in comparison to historical data.

Main Methods:

  • Retrospective review of 31 MVT patients diagnosed between 1985 and 1999.
  • Analysis of patient demographics, risk factors (hypercoagulability, surgery, prior thrombosis, cancer), and presenting symptoms.

Related Experiment Videos

  • Evaluation of diagnostic accuracy of Computed Tomography (CT) and angiography, and assessment of treatment outcomes including anticoagulation and surgery.

    • Main Results:

    • The 30-day mortality rate was 23% (7 of 31 patients).
    • Early anticoagulation with heparin was initiated in 72% of patients, with improved outcomes compared to those not heparinized.
    • CT scanning demonstrated high diagnostic accuracy (90-100%), while angiography was less sensitive (55.5%).
    • Long-term warfarin therapy was administered to 79% of survivors, with an 88% survival rate at a mean follow-up of 57.7 months.

    Conclusions:

    • MVT diagnosis should be considered in patients with acute abdominal symptoms and a history of thrombosis or coagulopathy.
    • CT scanning is the preferred diagnostic modality for MVT.
    • Early diagnosis and anticoagulation are recommended to prevent progression to gangrenous bowel and improve patient outcomes.