Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Combinatorial array-based enzymatic polyester synthesis.

D Y Kim1, J S Dordick

  • 1Department of Chemical Engineering, Rensselaer Polytechnic Institute, 102 Ricketts Bldg., Troy, NY 12180, USA.

Biotechnology and Bioengineering
|October 23, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Search for B→X_{s}νν[over ¯] Decays.

Physical review letters·2026
Same author

Search for Feebly Interacting Particles in B Decays with Missing Energy at Belle.

Physical review letters·2026
Same author

Lattice Radiation Therapy Delays Progression and Extends Survival for Dogs with Macroscopic Soft Tissue Sarcoma.

Radiation research·2026
Same author

Search for B^{0}→K^{*0}τ^{+}τ^{-} Decays at the Belle II Experiment.

Physical review letters·2025
Same author

Search for a Dark Higgs Boson Produced in Association with Inelastic Dark Matter at the Belle II Experiment.

Physical review letters·2025
Same author

Study of χ_{bJ}(2P)→ωϒ(1S) at Belle.

Physical review letters·2025
Same journal

Microbial Hydrolysates as Amino Acid Source in Cell Culture Media for Cellular Agriculture.

Biotechnology and bioengineering·2026
Same journal

LLM-Guided Parameter Optimization for Mechanistic CHO Cell Bioreactor Models.

Biotechnology and bioengineering·2026
Same journal

Three-Dimensional-Printed Polylactic Acid Scaffolds Coated With a Paeonol-Incorporated Gelatin/Bioactive Glass Composite Layer for Enhanced Osteogenic Performance.

Biotechnology and bioengineering·2026
Same journal

Recent Progress in Antimicrobial Peptides (AMPs) Towards Enhanced Selectivity and Reduced Cytotoxicity by Molecular Engineering.

Biotechnology and bioengineering·2026
Same journal

mZVI-Enhanced Mixed Nitrogen Removal in Klebsiella oxytoca via Coordinated Electron Transfer and Metabolic Reprogramming.

Biotechnology and bioengineering·2026
Same journal

Growth Model for Continuous Culture of a Hydrogen-Oxidizing Bacterium, Hydrogenophilus thermoluteolus Strain TH-1.

Biotechnology and bioengineering·2026
See all related articles

This study introduces a combinatorial method for creating polymer libraries using biocatalysis. Lipase-catalyzed polycondensation produced polymers up to 20,000 Da, including novel sugar-based polyesters.

Area of Science:

  • Polymer Chemistry
  • Biocatalysis
  • Materials Science

Background:

  • Traditional polymer synthesis often lacks efficiency and diversity.
  • Biocatalysis offers a sustainable and selective approach to polymer production.
  • Exploring diverse monomers is crucial for discovering novel polymeric materials.

Purpose of the Study:

  • To develop a combinatorial strategy for biocatalytic polymer synthesis.
  • To synthesize a diverse library of polymers using acyl donor-acceptor polycondensation.
  • To investigate the potential of complex monomers, including carbohydrates, in biocatalytic polymerization.

Main Methods:

  • Utilized AA-BB polycondensation reactions in 96 deep-well plates.
  • Employed a library of straight-chain diesters (C3-C10) as acyl donors.

Related Experiment Videos

  • Incorporated diverse acyl acceptors, including aliphatic/aromatic diols, carbohydrates, nucleic acids, and a steroid diol.
  • Used Candida antarctica lipase in acetonitrile as the biocatalyst.

    • Main Results:

    • Successfully synthesized a library of polymers with molecular weights up to 20,000 Da.
    • Demonstrated the biocatalytic synthesis of novel sugar-containing polyesters.
    • Confirmed the activity and efficacy of Candida antarctica lipase in acetonitrile for polycondensation.

    Conclusions:

    • The combinatorial approach enables efficient exploration of polymer structures.
    • Biocatalysis is a viable strategy for synthesizing polymers from complex and diverse monomers.
    • This method lays the groundwork for discovering new polymeric materials with tailored properties.