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[Lithium treatment and hyperparathyroidism].

F Dieserud1, A C Brun, P E Låhne

  • 1Psykiatrisk spesialtjeneste Fylkesavdeling Tønsberg Postboks 2084 3103 Tønsberg. f-die@online.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|October 24, 2001
PubMed
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Long-term lithium treatment can cause hyperparathyroidism. Surgical removal of parathyroid adenomas and switching mood stabilizers can effectively manage this condition, restoring normal calcium levels and mood.

Area of Science:

  • Endocrinology
  • Psychiatry
  • Oncology

Background:

  • Lithium is a common treatment for bipolar disorder.
  • Lithium use is associated with hypercalcemia and hyperparathyroidism.

Observation:

  • A patient on long-term lithium therapy developed hypercalcemia.
  • Following lithium cessation, the patient experienced depression and psychotic symptoms.

Findings:

  • The patient was diagnosed with hyperparathyroidism, with two parathyroid adenomas detected via scintigraphy.
  • Surgical removal of the adenomas and restarting lithium treatment resulted in normocalcemia and mood stabilization.

Implications:

  • Lithium-induced hyperparathyroidism may necessitate parathyroidectomy.

Related Experiment Videos

  • Alternative mood stabilizers are recommended if lithium cessation doesn't resolve hypercalcemia.