Iliofemoral thrombophlebitis associated with central nervous system pathology
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Updated: Aug 12, 2026
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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
American Journal of Surgery
|September 1, 1975
Insights
Acute thrombophlebitis in children is rare without a cause. Central nervous system disease was found in half of children with iliofemoral thrombophlebitis, suggesting a link.
Area of Science:
- Pediatric Hematology
- Pediatric Neurology
- Vascular Medicine
Background:
- Acute thrombophlebitis is uncommon in pediatric patients without a clear predisposing factor.
- Identifying underlying causes is crucial for effective management.
Purpose of the Study:
- To investigate the association between acute thrombophlebitis and central nervous system (CNS) disease in children.
- To highlight the importance of neurologic evaluation in pediatric thrombophlebitis cases.
Main Methods:
- Retrospective review of pediatric patients diagnosed with iliofemoral thrombophlebitis over a ten-year period.
- Analysis of medical records to identify co-existing central nervous system diseases.
Main Results:
- Eight children were diagnosed with iliofemoral thrombophlebitis during the study period.
- Four out of these eight children (50%) had an associated central nervous system disease.
Conclusions:
- A significant association exists between acute iliofemoral thrombophlebitis and central nervous system disease in children.
- Pediatric patients presenting with acute thrombophlebitis warrant a comprehensive neurologic assessment.
Abstract:
It is very uncommon for acute thrombophlebitis to develop in children without an identifiable predisposing cause. During a ten year period at a children's hospital, central nervous system disease was observed in four of eight children with iliofemoral thrombophlebitis. This association suggests that a thorough neurologic evaluation should be carried out in any child with acute thrombophlebitis.
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