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Related Experiment Videos

CD31 mismatching affects marrow transplantation outcome.

F C Grumet1, D D Hiraki, Brown BWM

  • 1Department of Pathology, Stanford University, California, USA. grumet@stanford.edu

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
|October 24, 2001
PubMed
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Donor-recipient CD31 nonidentity significantly increases risks for survival and severe acute graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). Matching at CD31 codons, particularly 563/670, is crucial for better BMT outcomes.

Area of Science:

  • Immunogenetics
  • Transplantation immunology
  • Hematology

Background:

  • Graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT) is often linked to minor histocompatibility antigens (mHags).
  • CD31 is a candidate human mHag, but its role in acute GVHD and the significance of its polymorphic codons remain debated.
  • Previous studies reported conflicting results regarding CD31's impact on BMT outcomes and HLA restriction.

Purpose of the Study:

  • To prospectively evaluate the impact of CD31 matching on BMT outcomes in HLA-identical sibling transplants.
  • To investigate the association between donor-recipient CD31 nonidentity at specific polymorphic codons and clinical outcomes.
  • To determine if CD31 matching is an independent risk factor for GVHD, survival, and relapse.

Main Methods:

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  • Prospective study of 118 HLA-identical sibling BMT pairs.
  • DNA typing for CD31 alleles at polymorphic codons 125, 563, and 670.
  • Correlation of CD31 nonidentity with severe acute GVHD, chronic GVHD, relapse, and survival rates.

Main Results:

  • Donor-recipient CD31 nonidentity at codon 563/670 (HR=2.58, P=.005) and codon 125 (HR=1.07, P=.036) significantly increased risks for overall survival.
  • Nonidentity at codon 563/670 (OR=11.15, P=.011) and codon 125 (OR=9.30, P=.030) were significant risk factors for severe acute GVHD.
  • CD31 nonidentity remained an independent risk factor for survival and severe acute GVHD in multivariate analysis.

Conclusions:

  • Donor-recipient CD31 nonidentity is a significant risk factor for survival and severe acute GVHD in HLA-identical sibling BMT.
  • Polymorphisms at codon 563/670 appear more critical than at codon 125 for BMT outcomes.
  • CD31 matching should be considered in BMT donor selection to improve patient survival and reduce GVHD.