Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytokeratin expression profiles in thyroid carcinomas.

K Y Lam1, M C Lui, C Y Lo

  • 1School of Medicine, James Cook University, Townsville, Queensland, Australia. akylam@hotmail.com

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|October 24, 2001
PubMed
Summary

This study established the cytokeratin (CK) expression profiles for various thyroid carcinomas. Papillary, follicular, poorly differentiated, anaplastic, and medullary thyroid cancers showed distinct CK7, CK18, and CK19 patterns.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risks and impacts of thromboembolism in patients with pancreatic cancer.

Hong Kong medical journal = Xianggang yi xue za zhi·2023
Same author

Modeling the Impact of pH- and Oxygen-Coupled Stimuli on Osmotic Pressure and Electrical Potential Responses of Hemoglobin-Loaded Polyampholyte Hydrogel.

ACS applied bio materials·2022
Same author

Epidemiology of paediatric orthopaedic-related trauma injuries sustained across a lockdown period during the COVID-19 pandemic.

Journal of orthopaedic surgery (Hong Kong)·2021
Same author

Report on outcomes of valve-in-valve transcatheter aortic valve implantation and redo surgical aortic valve replacement in the Netherlands.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2021
Same author

Sutureless aortic valve with supracoronary ascending aortic replacement as an alternative strategy for composite graft replacement in elderly patients.

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2021
Same author

Longitudinal Flow Decorrelations in Xe+Xe Collisions at sqrt[s_{NN}]=5.44  TeV with the ATLAS Detector.

Physical review letters·2021

Area of Science:

  • Oncology
  • Pathology
  • Biochemistry

Background:

  • Thyroid carcinomas exhibit diverse histological subtypes.
  • Cytokeratins (CKs) are intermediate filament proteins crucial for epithelial cell structure.
  • Specific CK profiles can aid in differentiating tumor types and understanding their behavior.

Purpose of the Study:

  • To determine the cytokeratin expression patterns in different types of thyroid carcinoma.
  • To establish a reference for CK expression in thyroid cancer diagnosis and subtyping.

Main Methods:

  • Immunohistochemistry was employed to examine the expression of cytokeratins (CKs) 1, 4, 6, 7, 10/13, 18, 19, and 20.
  • The study analyzed 153 thyroid carcinoma samples, including papillary, follicular, poorly differentiated, anaplastic, and medullary types.

Related Experiment Videos

Main Results:

  • Papillary and follicular carcinomas consistently expressed CK7 and CK18; CK19 was highly expressed in papillary and focally in follicular types.
  • Poorly differentiated and anaplastic carcinomas showed variable expression of CK7, CK18, and CK19.
  • Medullary carcinomas demonstrated high CK7 and CK18 expression, with focal CK19 positivity, and were negative for CK10/13.

Conclusions:

  • A distinct cytokeratin expression profile was established for each major type of thyroid carcinoma.
  • These findings can potentially improve the diagnostic accuracy and classification of thyroid neoplasms.
  • CKs 1, 4, 6, and 20 were not expressed in any of the analyzed thyroid carcinomas.