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Epstein-Barr virus complementary strand transcripts (CSTs/BARTs) and cancer.

P Smith1

  • 1Institute for Cancer Genetics and Pharmacogenomics, Department of Biology, Brunel University, Uxbridge, UB8 3PH, UK. p.r.smith@brunel.ac.uk

Seminars in Cancer Biology
|October 24, 2001
PubMed
Summary

Epstein-Barr virus (EBV) produces complementary strand transcripts (CSTs) or BARTs, highly expressed in nasopharyngeal carcinoma. These transcripts may encode proteins that influence Notch signaling pathways.

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Area of Science:

  • Virology
  • Molecular Biology
  • Oncology

Background:

  • Epstein-Barr virus (EBV) infection is widespread and associated with various cancers.
  • EBV encodes multiple transcripts, including the Bam A rightward transcripts (BARTs), also known as complementary strand transcripts (CSTs).
  • BARTs are notably upregulated in nasopharyngeal carcinomas, suggesting a role in tumorigenesis.

Purpose of the Study:

  • To investigate the significance of EBV-encoded complementary strand transcripts (CSTs/BARTs).
  • To explore the potential protein products of CSTs/BARTs.
  • To understand the functional implications of these transcripts, particularly their role in cellular signaling.

Main Methods:

  • Analysis of EBV transcript expression profiles in different infection types.

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  • Investigation of protein expression from CSTs/BARTs.
  • Functional studies assessing the impact of potential BART proteins on cellular pathways.

    • Main Results:

    • CSTs/BARTs are present in all EBV infections, with significantly higher levels in nasopharyngeal carcinomas.
    • Evidence suggests potential protein production from these transcripts, though direct confirmation is ongoing.
    • Potential BART proteins have been shown to modulate Notch signaling pathways.

    Conclusions:

    • CSTs/BARTs are a key feature of EBV biology, particularly in nasopharyngeal carcinoma.
    • The functional role of BART proteins in modulating cellular pathways like Notch signaling warrants further investigation.
    • Understanding BARTs' function may offer new insights into EBV-associated malignancies.