Synthesis and Characterization of the Platinum Cluster Complex Pt(4)(PF(3))(8)
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Updated: Oct 3, 2026
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Cynthia L. Hammill1, Ronald J. Clark, Charles W. Ross
1Department of Chemistry, Florida State University, Tallahassee, Florida 32306.
Abstract:
At temperatures approaching 200 degrees C, Pt(PF(3))(4) loses PF(3) and yields a cluster, Pt(4)(PF(3))(8). This composition has been confirmed by Fourier transform ion cyclotron resonance mass spectrometry, but its structure is unknown. At higher temperature, the monomer yields platinum metal (confirmed by X-ray diffraction) and the expected quantity of PF(3) gas. The PF(3) produced contains no observable impurities. Ligands such as olefins do not replace the PF(3) in Pt(PF(3))(4). However, ligands like P(OCH(3))(3) cause extensive replacement of the PF(3) ligand.
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