Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Raised serum TSH in hypothyroidism.

W Hamilton, J H Hutchison

    Archives of Disease in Childhood
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Early hypothyroidism can be detected by elevated serum thyroid-stimulating hormone (TSH) levels before other thyroid function tests show abnormalities. Measuring TSH is crucial for diagnosing mild thyroid insufficiency.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Publisher Correction: Muscle abnormalities in Long COVID.

    Nature communications·2025
    Same author

    Reply: Muscle abnormalities in Long COVID.

    Nature communications·2025
    Same author

    COLOFIT: Development and Internal-External Validation of Models Using Age, Sex, Faecal Immunochemical and Blood Tests to Optimise Diagnosis of Colorectal Cancer in Symptomatic Patients.

    Alimentary pharmacology & therapeutics·2025
    Same author

    Prediction of m6A and m5C at single-molecule resolution reveals a transcriptome-wide co-occurrence of RNA modifications.

    Nature communications·2024
    Same author

    Anthrax in a Horse.

    The Journal of comparative medicine and veterinary archives·2022
    Same author

    Pulmonary nodules.

    BMJ (Clinical research ed.)·2020

    Area of Science:

    • Endocrinology
    • Thyroid Disorders
    • Clinical Diagnostics

    Background:

    • Conventional thyroid function tests may not detect early or mild hypothyroidism.
    • Subtle thyroid insufficiency can precede detectable decreases in serum thyroxine (T4) and triiodothyronine (T3).

    Observation:

    • A patient presented with a significantly elevated serum TSH level (310 muU/ml).
    • Other standard thyroid function tests in this patient yielded normal results.

    Findings:

    • Serum TSH levels rise in mild hypothyroidism before T4 and T3 levels decline.
    • Normal serum TSH concentrations effectively exclude thyroid insufficiency.
    • Elevated serum TSH confirms mild hypothyroidism, even with normal T4 and T3.

    Implications:

    Related Experiment Videos

    • Assaying serum TSH is essential for diagnosing early and mild hypothyroidism.
    • TSH measurement provides a sensitive marker for thyroid dysfunction.
    • Early detection allows for timely intervention and management of thyroid insufficiency.