Related Experiment Video
Updated: May 3, 2026

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Coupling of Amino Carboranes to Carboxylic Acid Containing Substrates
1Department of Chemistry and Biochemistry, New Mexico State University, Box 30001, Department 3C, Las Cruces, New Mexico 88003-8001.
Abstract:
The reactivity of the known amino carboranes 1-H(2)NCH(2)-1,2-C(2)B(10)H(11) and 7-H(3)N-7-CB(10)H(12) with carboxylic acid containing substrates was investigated. The reactions studied using the coupling reagent, 1,1'-carbonyldiimidazole, resulted in the preparation of a series of amides in moderate to high yield. The relative importance of this type of research resides in the fact that it allows the introduction of amino acids in close contact with the carborane cage. These compounds can constitute a new generation of substrates useful in boron neutron capture therapy. Our emphasis lies in the development of suitable synthetic schemes allowing the preparation of this type of compound. Experimental details and analytical data supporting the formulation of the prepared compounds are reported.
Related Concept Videos
Nucleophilic Acyl Substitution of Carboxylic Acid Derivatives
Nitriles to Carboxylic Acids: Hydrolysis
Conjugate Addition to α,β-Unsaturated Carbonyl Compounds
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
Preparation of Carboxylic Acids: Hydrolysis of Nitriles
Reactions of Carboxylic Acids: Introduction

